Adult onset spinal muscular atrophy

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Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed. Proximal spinal muscular atrophy type 4 SMA4 is the adult-onset form of proximal spinal muscular atrophy see this term characterized by muscle weakness and hypotonia resulting from the degeneration and loss of the lower motor neurons in the spinal cord and the brain stem nuclei. SMA4 usually manifests in the second or third decade of life. The muscle weakness predominantly affects the legs and hip muscles and then progresses to the shoulders and arms.
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Spinal Muscular Atrophy Type 4

This website translates English to other languages using an automated tool. We cannot guarantee the accuracy of the translated text. Spinal muscular atrophy is a group of inherited diseases that affect the muscles responsible for voluntary movement in the body. This disease occurs when there is damage to the motor neurons, specialized nerve cells that facilitate communication with the muscles. This damage keeps the muscle from contracting, which leads to muscle weakness and atrophy. Depending on the age of onset, severity and genetic cause there are several different types of the disease: spinal muscular atrophy Types 1, 2, 3 and 4, X-linked spinal muscular atrophy, and spinal muscular atrophy, lower-extremity dominant SMA-LED. Symptoms of spinal muscular atrophy Type 1 are evident at birth or within the first few months of life.
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Adult-onset spinal muscular atrophy: An update.

Spinal muscle atrophy SMA is a serious heritable condition characterized by the loss of motor neurons, or nerve cells responsible for carrying instructions from the brain to the muscles to control their movement. Without these nerve cells, muscles weaken and atrophy. Patients with SMA may have difficulty standing, walking, and dressing. Swallowing, speaking, and breathing may also be affected.
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You may prefer to read this as a printed version — use the print button at the top right of this page. If you are in the UK, you can ask us to send it to you in booklet form. This guide is for adults who have had a recent diagnosis of an adult onset form of SMA. There are other forms of adult onset SMA with different causes. The impact of adult onset SMA varies greatly between individuals.
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